The Toronto native dropped Brown's ex's name—Karrueche Tran—during one of the tracks on the highly anticipated collaboration, which was dropped late Sunday evening.
The track in question is "Live from the Gutter" where Drake raps, "This is for my n---as on that bulls--t and that nonsense, this is for my dawgs that go Karrueche with the chopsticks."
Brown immediately hopped on social media and posted a video on Instagram reacting to the lyrics, without ever actually naming the "Started From the Bottom" rapper.
"I'm too blessed for the bulls—t. People who have had to sit and watch me for years do me and watch their females actually love me always show their insecurities," Brown wrote as the caption to the photo.
He continued with, "I embrace anything God has given me. It's bigger than this music s--t. I'm content with being Chris Brown. A lot of people are unhappy and a lot of these artists lie to the fans or rely on hype to gain substance. You n---as bore me. Ima keep being who God made me to be! 100 #IAMMUSIC #Othersbarelyholdanote #thesehandsworkgreat."
This is just the latest in the drama between Drake and Brown, who both famously had a violent run-in at a New York City club reportedly over Rihanna.
"Two rappers fighting over the woman. He's not even a rapper, but still, it's the last way you want your name out there," Drake told GQ magazine back in 2013.
"It distracts from the music. But he's made me the enemy, and that's the way it's gonna stay, I guess."