First five Danny Cipriani will make his first start for England in nearly a decade and there is a return for flanker Chris Robshaw, with coach Eddie Jones shuffling his team for the third and final rugby Test against South Africa.
Cipriani replaces George Ford in the number 10 jersey as one of four changes to the starting line-up announced by Jones as England seek to end a run of five straight Test defeats and grab a consolation victory.
Cipriani's last start came in a 42-6 loss to the Springboks at Twickenham in 2008, though he has won 15 caps in all, his most recent off the bench in the 23-12 defeat in Bloemfontein last weekend after an absence of three years from the team.
"We are expecting a wet and windy old day at Newlands and have elected to play Danny Cipriani ahead of George Ford to give us a left-foot kicking option," Jones said.
"We will need to jump out of the blocks quickly again and make sure we maintain that pressure and make good decisions."
Robshaw, previously a stalwart under Jones, is recalled to the blindside flank position after New Zealand-born Brad Shields dropped out of the squad due to illness.
Prop Joe Marler comes into the side in place of Mako Vunipola, who has returned home for family reasons, while Nathan Hughes takes over at number eight from Billy Vunipola, who re-fractured his arm in last weekend's loss in Bloemfontein.
Uncapped lock Jonny Hill has been included among the replacements.
Team: Elliot Daly, Jonny May, Henry Slade, Owen Farrell (capt), Mike Brown, Danny Cipriani, Ben Youngs, Nathan Hughes, Tom Curry, Chris Robshaw, Maro Itoje, Joe Launchbury, Kyle Sinckler, Jamie George, Joe Marler
Replacements: Luke Cowan-Dickie, Alec Hepburn, Harry Williams, Jonny Hill, Mark Wilson, Sam Simmonds, Ben Spencer, Denny Solomona.