The 40-year-old man, known as "Mike" is alleged to head a network of 40 individuals behind global scams worth more than $60m (£45m).
His operations involves using targeted malware to take over systems, use compromised emails and romance scams.
Nigeria's anti-fraud agency was also involved in the arrest.
"In one case, a target was conned into paying out $15.4 m (£11m)," Interpol said in a statement.
"Mike" also allegedly ran a money laundering network in China, Europe and the US.