The International Paralympic Committee (IPC) had opened suspension proceedings following the McLaren report, and has now confirmed the ban.
The report, published last month, claimed Russia had operated a state-sponsored doping programme.
The International Olympic Committee (IOC) chose not to give Russia a blanket ban from the Olympic Games.
"The anti-doping system in Russia is broken, corrupted and entirely compromised," said IPC president Sir Philip Craven at a news conference on Sunday.
"The Russian Paralympic Committee are unable to ensure compliance with and enforcement of the IPC anti-doping code and the world anti-doping code within their own national jurisdiction and they can not fulfil its fundamental obligation as an IPC member.
"As a result, the Russian Paralympic Committee is suspended with immediate effect."