The grim milestone comes amid growing political unrest and days after the country confirmed more than one million coronavirus infections.
Experts warn that the peak of the outbreak in Brazil is still weeks away.
The World Health Organization (WHO) has recorded the biggest one-day increase in cases, with the Americas responsible for most of the new infections.
Of the 183,000 new cases reported in 24 hours, more than 60% were from North and South America, the agency said.
However, the growing outbreak did not stop thousands of supporters and opponents of Brazil's far-right President Jair Bolsonaro from taking to the streets in rival protests on Sunday.
Anti-government demonstrators are calling for Mr Bolsonaro to be impeached. It follows the arrest on Thursday of a former aide and family friend who is accused of corruption.
His supporters say Congress and the Supreme Court are trying to curb his powers.
Mr Bolsonaro has also been heavily criticised for his response to the coronavirus outbreak. He has opposed lockdowns and openly disagreed with advice from his government's own health ministry.
On Sunday, the ministry announced that 641 more deaths had been registered in the past 24 hours, taking the total to 50,617. Over the same period it also registered more than 17,000 new infections.
Only the US has fared worse, with 2.2 million cases and nearly 120,000 deaths.