Head coach Vaovasamanaia Seilala Mapusua has named Paul-Alo Emile in the front row, Paul Ala'nu'uese at locks and Ben Lam on the wing in the Rugby World Cup battle.
Lock Chris Vui gets to lead the team out with his co-captain and prop Michael Ala'alatoa on the bench.
Samoa needs to win the clash to give them an advantage over the Pumas, who lost their first game to England a fortnight ago.
England has two wins and leads on the points table.
Samoa are second but need the win to give them a better chance of qualifying for the quarterfinals.