Manu Tuilagi

The 27-year-old, who has suffered a string of injuries over the past few seasons, starts at 12 in the absence of injured Ben Te'o.

Elliot Daly is preferred at full-back to Mike Brown, who is left out of the 23-strong matchday squad.

George Kruis partners fellow Saracen Maro Itoje in the second row.

Owen Farrell starts at fly-half, with Henry Slade partnering Tuilagi in midfield and George Ford on the bench, while flankers Tom Curry and Mark Wilson make their first Six Nations appearances.

Leicester Tigers powerhouse Tuilagi last represented England in the 2016 Six Nations having been dogged by injuries, the latest a knee problem that has sidelined him since January.

The centre was included in a 37-man squad that met for a pre-season training camp in Teddington and was set to be among the players attending the launch of England's new team kit on Monday.

However, he will no longer be attending with the RFU saying via a short statement: "Denny Solomona and Manu Tuilagi have been sent home today from England's training camp following team culture issues.

Tuilagi, who last represented England in the 2016 Six Nations, has been named in a 37-man squad that will meet up for a pre-season training camp this weekend.

"It's nice to see him back training and back into it. He was a player who demolished New Zealand," said Jones of the Leicester Tigers back.

"If his motivation and desire is right then he can be an outstanding player for us and add to the depth of the squad."

Tuilagi, who last played for England in 2014, has been out for 15 months with groin and hamstring problems.

Exeter flanker Dave Ewers is also included in the squad, after recovering from a knee injury.

England lead the Six Nations with three wins from three games, while Wales are unbeaten going into the 12 March match.

The Samoan-born England international, who is out of action with a long-term groin injury, agreed to a deal that will earn the 24-year-old more than £425,000-a-year with the East Midlands club.

The contract puts him among the world's richest players, and Tigers director of rugby Richard Cockerill praised Tuilagi's loyalty after he knocked back lucrative offers from Wasps, Worcester, Saracens and Toulouse.

"Manu is in the prime of his rugby life," Cockerill told the Daily Mail.

The Samoa-born hulking centre was discarded from England's World Cup disaster when coach Stuart Lancaster's hard-line disciplinary attitude in the leadup to the tournament saw Tuilagi dropped after he was convicted of assaulting two female police officers and damaging a taxi.

Now the recent hike in the salary cap by $2.13m is set to earn the 24-year-old Samoan a fortune as a bidding war for his services escalates.

Last month Saracens offered Tuilagi a $920,000 deal.