Prop WP Nel (arm fracture) and lock Tim Swinson (hand) will miss the remainder of 2017, which also includes a test against Australia on November 25, after picking up injuries in the 44-38 victory over Samoa on Saturday.
Flanker Rob Harley, who injured his knee in training last week, will also not feature again this year.
Newcastle Falcons prop Jon Welsh has been added to the squad as cover and could play his first test in more than two years having last appeared in the 2015 Rugby World Cup quarterfinal loss to Australia at Twickenham.