Medvedev, playing in his third major final, at last hoisted a Grand Slam trophy while avenging a straight sets defeat by Djokovic earlier this year in the Australian Open final.
The Serb was trying to become the first man in over a half-century to win all four majors (Australian Open, French Open, Wimbledon, U.S. Open) in the same year.
For the fifth consecutive match, Djokovic found himself in an early hole after dropping the first set.
