Instead of its usual Los Angeles location it will be held digitally and free for everyone to attend due to the pandemic.
Nintendo, Xbox, Konami and Ubisoft are some of the developers which have agreed to participate.
Notably absent are EA, Activision and Sony, but this isn't unusual and often happened before the pandemic too.
The show, which connects developers and publishers with gamers was forced to cancel last year due to global lockdowns.
Entertainment Software Association, which runs the event, hasn't yet given any clues about how it will take hold.
Fans will be expecting to see lots of trailers, game demonstrations and pre-filmed interviews with the biggest names in the industry.
The whole event will be free to take part in - with no VIP packages or paywall features.