Serious and Organised Crime Branch detectives said the four accused were working independently of each other.
Three alleged offenders, a 30-year-old Adelaide man, a 23-year-old from Angle Vale and a 25-year-old man from Greenwith, are facing charges of trafficking a controlled drug.
A 32-year-old man from Aldgate is charged with trafficking a controlled drug, along with cultivation of a controlled plant for sale, possessing prescribed equipment and possessing a controlled drug for sale.
All are to face Adelaide Magistrates Court.
