The aircraft operated by Hainan Airlines landed at Faleolo International Airport on Sunday evening.
The flight originated from the Haikou Meilan International Airport in Hakou in the Hainan Province.
According to the Samoa Government, there were more than 200 mainly business people from China in a major achievement that has been 10 years in the making.
The passengers on the direct flight will stay in Samoa for eight days before the next flight brings in another group of tourists.
The return flights from Samoa to China are available for travel and cargo.
