She becomes the first woman in the history of Super Rugby to do so.
RNZI reports Perrett, a full-time professional referee, officiated in the women's Rugby World Cup final and was selected as one of Australia's two representatives for the Rio Olympics in August.
"I am really proud to be given this honour this weekend and I certainly hope this opens the door for more women to officiate the top level across rugby," the 25-year-old said in a statement released by Super Rugby.
"I am just focused on doing my job to the best of my ability and will be joining a fantastic team of SANZAAR referees right across Australia, New Zealand, South Africa and Argentina who referee Super Rugby week in and week out."
Perrett came through the ranks of the Australian Rugby Referees Pathways programme, and will assist main referee Angus Gardner during the game in Melbourne.
Amy's rise to Super Rugby has been benefited by her coming on as a full time professional referee sharing her time between Australian Rugby and NSW Rugby in early 2016.
No stranger to big match pressure, Perrett has previously refereed Finals of Women's Sevens tournaments, the Women's Rugby World Cup Final and the Women's Six Nations major derby between England and France.