The sports star, who captained England and played for clubs including Manchester United and Real Madrid, will return to the east London pitches where he played as a child.
His mission is to help a struggling side survive in their amateur league.
Disney says the team and their community will go on "an uplifting, transformative journey of a lifetime".
Beckham said: "It is fantastic to be making Save Our Squad and to shine a light on the kind of grassroots football that I experienced growing up and which gave me so much at the start of my life in the game.
"I was so fortunate to have a long and successful playing career and now to have the opportunity to give back to these communities as a mentor is incredible.
"Developing and nurturing young talent is so important in the game and it is great to be working with Disney+ on this project."
The show will be made by production company Twenty Twenty and Studio 99, a production studio Beckham co-founded.
It's not yet known when the series will air.