Josh Tyrell comes back into the second row, in place of Faatiga Lemalu, after missing the defeat by Romania in Bucharest.
TJ Ioane gets the start at openside flanker, with Jack Lam shifting to number eight in place of Ofisa Treviranus.
Meanwhile Alapati Leiua will make his first start on tour at second five eighth in place of Reynold Lee-Lo, who drops to the bench.
Samoa have yet to beat England in seven previous tests, with the hosts prevailing 28-9 in their last meeting at Twickenham in 2014.
Samoa squad:
1. Jordan Lay
2. Motu Matu'u
3. Donald Brighouse
4. Josh Tyrell
5. Chris Vui (c)
6. Piula Faasalele
7. TJ Ioane
8. Jack Lam
9. Dwayne Polataivao
10. Tim Nanai Williams
11. David Lemi
12. Alapati Leiua
13. Kieron Fonotia
14. Paul Perez (vc)
15. Ah See Tuala
16. Manu Leiataua
17. James Lay
18. Hisa Sasagi
19. Faatiga Lemalu
20. Maurie Faasavalu
21. Melani Matavao
22 Reynold Lee-Lo
23. JJ Taulagi