Moyano is still recovering from a rib injury sustained in the Pumas' victory against Australia on the Gold Coast earlier this month.
Moyano was one of Argentina's standout performers in their 46-24 loss to the All Blacks in Nelson in Round three.
The former Argentina Sevens representative also scored a try in Argentina's 32-19 victory over South Africa in Mendoza last month.
Apart from Moyano, Argentina head coach Mario Ledesma has also left out back-up first-five Joaquin Diaz Bonilla, prop Enrique Pieretto and back-row duo Leonardo Senatore and Rodrigo Bruni of a 30-man squad for this weekend's Test.
Forwards: Forwards: Matias Alemanno, Diego Fortuny, Santiago Garcia Botta, Agustin Creevy (c), Ramiro Herrera, Marcos Kremer, Tomas Lavanini, Juan Manuel Leguizamon, Tomas Lezana, Pablo Matera, Santiago Medrano, Julian Montoya, Javier Ortega Desio, Guido Petti, Nahuel Tetaz Chaparro, Juan Zeiss
Backs: Gonzalo Bertranou, Emiliano Boffelli, Sebastian Cancelliere, Tomas Cubelli, Santiago Alvarez Fourcade, Jeronimo de la Fuente, Bautista Delguy, Bautista Ezcurra, Santiago Gonzalez Iglesias, Martin Landajo, Juan Cruz Mallia, Matias Moroni, Matias Orlando, Nicolas Sanchez