Messi left Newell's for Barca at the age of 13 and has gone on to become one of the greatest players of all time, winning the Ballon d'Or on five occasions.
The 29-year-old has previously indicated a desire to end his career in Catalonia, but he appeared drawn to a Newell's return during an interview with Telefe's Polemica en el Bar in his homeland.
"I would love to [return]," he said. "It is something I have kept an eye on because it was my dream as a child.
"Obviously my life started to change and went another way, but I have no regrets.