With the defending world champion Shelly-Ann Fraser-Pryce pregnant and not in London, Thompson is the runaway favourite to follow up her 2016 Olympic 100m title with another gold medal.
The Jamaican has recorded the two fastest times this year and she showed her proven class by bursting out of the blocks in her semi-final.
Thompson won in a fine time of 10.84 seconds ahead of Brazil's Rosangela Santos, who set a South American record in second, and she will be hard to stop in Sunday's showpiece final.
