Macrolides, quinolones, tetracyclines, sulfonamides and metronidazole were related to higher rates of pregnancy loss, the researchers say. However, a greater chance of pregnancy loss was not seen with the most frequently used antibiotics, including penicillin.
"It is reassuring to see that first-line treatments and antibiotics that are the most used in the population (penicillin, cephalosporin) were not associated with an increased risk of miscarriage," Dr. Anick Bérard, lead researcher and a member of the Faculty of Pharmacy at the Université de Montréal, wrote in an email.