The star was awoken by a security alarm in the early hours of the morning, after someone broke into his gated Detroit-area home.
The 47-year-old found the intruder in his living room. His security guard arrived shortly afterwards, followed by the police.
The suspect was later arrested and remains in custody.
It is understood the intruder entered via the rear of the house, while the rapper's security guard was at the front of the property.
The star, whose real name is Marshall Mathers, was awoken by a security alarm, and found the suspect in his living room.