He confirmed one patient in a quarantine facility tested positive to the coronavirus on Wednesday night.
However Tuila'epa said a second confirmatory test came back negative when conducted this morning.
The man was a sailor who arrived in Samoa on a repatriation flight from Auckland last Friday.
He has been placed in an isolation ward at Tupua Tamasese Motootua hospital.
The prime minister said the country would not take any chances as the man could transmit the coronavirus to others.
