Its brain signals were sent wirelessly via an implanted device.
The hope is that the interface could eventually allow people with neurological conditions to control phones or computers remotely.
One expert said the fact no wires were used represented "significant progress", but more data was needed.
The macaque monkey, named Pager, was first taught to play the video game with a joystick, and was rewarded with a fruit smoothie.
During this process, the Neuralink device recorded the information about which neurons were firing to control which movements.
