Wayne Bennett's England squad will play the mid-season game ahead of the World Cup in Australia, New Zealand and Papua New Guinea, which starts in October.
In addition, Fiji will play Tonga and Papua New Guinea face the Cook Islands.
Campbelltown Sports Stadium is one of the outgrounds used by NRL club Wests Tigers, and has a capacity of 20,000.
BBC reports the last time England and Samoa met was in the 2014 Four Nations, which ended in a 32-26 win for the northern hemisphere side.
