Jackson Garden-Bachop suffered an achilles injury playing against the Crusaders in round two and now needs surgery.
It leaves the Hurricanes without their top two first-fives after Simon Hickey suffered a season-ending knee injury during pre-season.
Orbyn Leger will start in the number ten jersey again after debuting for the Hurricanes in last weekend's loss to the Chiefs.
Young prospect Ruben Love, a possible first five backup, is set for his first game time after being named on the bench.
Fullback Jordie Barrett could also fill in at number ten.