The clash at Twickenham is the only match to be played from Samoa's original end-of-year tour, with earlier tests against Georgia, Uruguay and Spain cancelled because of Covid-19 travel restrictions.
Head coach Vaovasamanaia Seilala Mapusua has selected a balanced squad including ten debutants and a handful of wily veterans.
Veteran lock Joe Tekori will make his swansong appearance for the Manu next Saturday, fresh from scoring a try for the French Barbarians in their win over Tonga.
