The unbeaten 33-year-old is a two-time world champion, winning 31 of 32 professional fights.
He drew with American Deontay Wilder in the first of their three fights, before winning the second and third bouts.
Asked whether he would call time on his career after fighting Whyte at Wembley Stadium on 23 April, Fury said: "100%."
Speaking after his news conference to promote his upcoming bout, Fury said: "I'm a two-time undisputed world champion.
"[I have] £150m in the bank and nothing to prove to anybody."